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Coexistent gastric MALT lymphoma and Kaposi sarcoma in an HIV positive patient.

机译:HIV阳性患者同时存在胃MALT淋巴瘤和卡波西肉瘤。

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摘要

A 47 year old HIV positive male presented with haematemesis and epigastric pain. A gastrectomy was performed for intractable bleeding. The cause of the haematemesis proved to be a Kaposi sarcoma of the stomach which had resulted in mucosal ulceration. Several other smaller foci of Kaposi sarcoma were also present. Coexistent with the Kaposi sarcoma was a dense lymphoid infiltrate with lymphoid follicles and reactive germinal centres. Centrocyte-like cells caused marked effacement and destruction of gastric glands with the formation of lymphoepithelial lesions, typical of a MALT lymphoma. These cells were of B cell lineage and some expressed the HIV antigen, p24. Follicular dendritic cells and macrophages within germinal centres were also p24 positive. Immunohistochemistry and in situ hybridisation did not detect Epstein-Barr virus. Although Helicobacter pylori was not identified by light microscopy in the sections sampled, this does not preclude its possible role, with other cofactors such as HIV, in the causation of the MALT lymphoma.
机译:一位47岁的HIV阳性男性表现为呕血和上腹痛。进行胃切除术治疗顽固性出血。呕血的原因被证明是胃的卡波济肉瘤,其导致了粘膜溃疡。还存在卡波西肉瘤的其他几个较小的病灶。与卡波济肉瘤并存的是有淋巴滤泡和反应性生发中心的致密淋巴样浸润。类似于类MALT淋巴瘤的淋巴细胞样上皮样细胞引起胃腺的明显污损和破坏,并形成了上皮性病变。这些细胞属于B细胞谱系,其中一些表达HIV抗原p24。生发中心内的滤泡树突状细胞和巨噬细胞也呈p24阳性。免疫组织化学和原位杂交未检测到爱泼斯坦-巴尔病毒。尽管在取样的切片中未通过光学显微镜鉴定出幽门螺杆菌,但这并不排除它与其他辅助因子(如HIV)在引起MALT淋巴瘤方面的可能作用。

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  • 作者

    Chetty, R; Pillay, S V;

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  • 年度 1999
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  • 正文语种 en
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